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KMID : 1161420120150100936
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Journal of Medicinal Food
2012 Volume.15 No. 10 p.936 ~ p.944
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Anti-Atherogenic Effects of a Phenol-Rich Fraction from Brazilian Red Wine (Vitis labrusca L.) in Hypercholesterolemic Low-Density Lipoprotein Receptor Knockout Mice
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Hort Mariana Appel
Schuldt Elke Zuleika
Bet Angela Cristina
DalBo Silvia
Siqueira Jarbas Mota
Ianssen Carla
Abatepaulo Fatima
de Souza Heraldo Possolo
Veleirinho Beatriz
Maraschin Marcelo
Ribeiro-do-Valle Rosa Maria
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Abstract
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Moderate wine intake (i.e., 1?2 glasses of wine a day) is associated with a reduced risk of morbidity and mortality from cardiovascular disease. The aim of this study was to evaluate the anti-atherosclerotic effects of a nonalcoholic ethyl acetate fraction (EAF) from a South Brazilian red wine obtained from Vitis labrusca grapes. Experiments were carried out on low-density lipoprotein (LDL) receptor knockout (LDLr?/?) mice, which were subjected to a hypercholesterolemic diet and treated with doses of EAF (3, 10, and 30?mg/kg) for 12 weeks. At the end of the treatment, the level of plasma lipids, the vascular reactivity, and the atherosclerotic lesions were evaluated. Our results demonstrated that the treatment with EAF at 3?mg/kg significantly decreased total cholesterol, triglycerides, and LDL plus very low-density lipoprotein levels compared with control hypercholesterolemic mice. The treatment of mice with EAF at 3?mg/kg also preserved the vasodilatation induced by acetylcholine on isolated thoracic aorta from hypercholesterolemic LDLr?/? mice. This result is in agreement with the degree of lipid deposit on arteries. Taken together, the results show for the first time that the lowest concentration of an EAF obtained from a red wine produced in southern Brazil significantly reduced the progression of atherosclerosis in mice.
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KEYWORD
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atherosclerosis, hypercholesterolemia, phenolic compounds, red wine, Vitis labrusca
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